Mola

Mola | sequence-to-distribution model

Model

Mode

Region hg38 Seqstr 10 kb window; longer intervals are centre-cropped Variants @chr pos REF ALT

Molecules to sample

Queued

Observed Fiber-seq Show observed molecules

Show m6A FiberHMM calls MSP (accessible patch) Nucleosome TF footprint

Accessibility signal Sort fibers Co-accessibility bin

chr10:92,587,000-92,597,000 Simulated

Connecting…

Mean accessibility

Difference

Δ accessibleΔ TF footprintvariant − reference

Single molecules

Single molecules · Variant

Single molecules · Observed

Co-accessibility

Co-accessibility · Variant

Co-accessibility · Observed

Co-accessibility · Difference variant − reference